Suvas Susmit, Rouse Barry T
Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0845, USA.
Curr Opin Immunol. 2006 Jun;18(3):344-8. doi: 10.1016/j.coi.2006.03.005. Epub 2006 Apr 17.
Immunity to microbes depends on the function of numerous cell types and their products. These include T cells with regulatory function (Treg) against the components of the immune system. Recently, there has been much discussion regarding the circumstances in which protective or tissue-damaging T cell responses to microbes are affected by the activity of Treg. These relationships range from situations in which the Treg response seems to contribute to immune dysfunction to those that minimize tissue damage caused by immunoinflammatory T cell reactions. In several parasitic infections, Treg maintain equilibrium to ensure parasite persistence, minimal tissue damage and immunity to re-infection. Recently, several unresolved questions about the role of Treg in microbial infections have been raised and discussed. Learning how to successfully manipulate Treg responses could result in more effective vaccines and immunomodulators.
对微生物的免疫依赖于多种细胞类型及其产物的功能。这些包括对免疫系统成分具有调节功能的T细胞（调节性T细胞）。最近，关于调节性T细胞的活性影响对微生物的保护性或组织损伤性T细胞反应的情况，已经有很多讨论。这些关系涵盖了从调节性T细胞反应似乎导致免疫功能障碍的情况到使免疫炎性T细胞反应引起的组织损伤最小化的情况。在几种寄生虫感染中，调节性T细胞维持平衡以确保寄生虫持续存在、使组织损伤最小化并产生对再感染的免疫力。最近，已经提出并讨论了一些关于调节性T细胞在微生物感染中的作用的未解决问题。了解如何成功地操控调节性T细胞反应可能会产生更有效的疫苗和免疫调节剂。
