Enarsson Karin, Lundgren Anna, Kindlund Bert, Hermansson Mikael, Roncador Giovanna, Banham Alison H, Lundin B Samuel, Quiding-Järbrink Marianne
Inst. of Biomedicine, Dept. of Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Göteborg, Sweden.
Clin Immunol. 2006 Dec;121(3):358-68. doi: 10.1016/j.clim.2006.07.002. Epub 2006 Aug 23.
CD4(+)CD25(high) FOXP3-expressing regulatory T cells (Treg) can suppress immune responses to infections and tumors, thereby promoting microbial persistence and tumor progression. However, little is known about the phenotype and function of human mucosal Treg. Therefore, we analyzed the suppressive activity and homing phenotype of Treg in gastric mucosa of Helicobacter pylori-infected gastric adenocarcinoma patients. We found increased numbers of CD4(+)FOXP3(+) Treg in the tumor compared to tumor-free gastric mucosa. Gastric Treg cells were able to suppress H. pylori-induced T cell proliferation and IFN-gamma production. Furthermore, gastric Treg expressed increased levels of l-selectin and CCR4, compared to non-Treg cells, suggesting that these receptors contribute to Treg recruitment. The presence of functional antigen-specific Treg in H. pylori-infected gastric mucosa supports an important role for these cells in suppression of mucosal effector T cell responses, which probably contribute to bacterial persistence and possibly also to gastric tumor progression.
表达CD4(+)CD25(高)FOXP3的调节性T细胞（Treg）可抑制针对感染和肿瘤的免疫反应，从而促进微生物持续存在和肿瘤进展。然而，关于人类黏膜Treg的表型和功能知之甚少。因此，我们分析了幽门螺杆菌感染的胃腺癌患者胃黏膜中Treg的抑制活性和归巢表型。我们发现，与无肿瘤的胃黏膜相比，肿瘤中CD4(+)FOXP3(+) Treg数量增加。胃Treg细胞能够抑制幽门螺杆菌诱导的T细胞增殖和IFN-γ产生。此外，与非Treg细胞相比，胃Treg表达的L-选择素和CCR4水平升高，表明这些受体有助于Treg募集。幽门螺杆菌感染的胃黏膜中功能性抗原特异性Treg的存在支持了这些细胞在抑制黏膜效应T细胞反应中起重要作用，这可能有助于细菌持续存在，也可能导致胃肿瘤进展。
