铃木型钯（0）偶联反应在合成作为细胞周期蛋白依赖性激酶（Cdk）抑制剂的2-芳基嘌呤中的应用
Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors.
作者信息
Vandromme Lucie, Piguel Sandrine, Lozach Olivier, Meijer Laurent, Legraverend Michel, Grierson David S
机构信息
UMR 176 CNRS-Institut Curie, Institut Curie Section de Recherche, Bât. 110, Centre Universitaire, 91405 Orsay, France.
出版信息
Bioorg Med Chem Lett. 2006 Jun 15;16(12):3144-6. doi: 10.1016/j.bmcl.2006.03.060. Epub 2006 Apr 17.
PMID:16616489
Abstract
A new series of 2-aryl-substituted purine derivatives has been synthesized by Suzuki Pd(0) coupling reactions. Moderate in vitro inhibitory activity against Cdk1 and Cdk5 was observed. These compounds are inactive against GSK3.
摘要
通过铃木钯（0）偶联反应合成了一系列新的2-芳基取代嘌呤衍生物。观察到其对Cdk1和Cdk5具有中等的体外抑制活性。这些化合物对GSK3无活性。
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