Mendis Eresha, Kim Moon-Moo, Rajapakse Niranjan, Kim Se-Kwon
Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.
Bioorg Med Chem Lett. 2006 Jun 15;16(12):3105-10. doi: 10.1016/j.bmcl.2006.03.077. Epub 2006 Apr 17.
Experimental evidences have confirmed that matrix metalloproteinases (MMPs) play a fundamental role in a wide variety of pathologic conditions and recent advances in medicinal chemistry approach to the design of MMP inhibitors with desired structural and functional properties. Among MMPs, MMP-9 has demonstrated to play a major role in the establishment of metastases and it is substantially increased in the majority of malignant tumors. Inhibition of MMP-9 is thought to have a therapeutic benefit to cancer. Results of this study present a novel synthetic MMP-9 inhibitor that downregulates MMP-9 expression level in HT1080, human fibrosarcoma cells.
