Patel S, Stolerman I P, Asherson P, Sluyter F
Section of Behavioural Pharmacology, Institute of Psychiatry P049, Kings College London, De Crespigny Park, London SE5 8AF, UK.
Behav Brain Res. 2006 Jun 30;170(2):197-203. doi: 10.1016/j.bbr.2006.02.019. Epub 2006 Apr 17.
C57BL/6 and DBA/2 were compared in the 5-choice serial reaction time task for differences in performance related to attention and impulsivity. The goal was to examine behavioural processes in mice that may relate to ADHD in humans. Groups of male mice were trained to nose-poke in response to a stimulus light presented randomly in one of five holes; correct responses were reinforced with food. During training the stimulus duration (SD) was reduced progressively from 60 to 0.5s. The C57BL/6 and DBA/2 mice did not differ during early stages of training when attentional demands were low (SD of 60, 10 or 5s). As task demands increased, strain differences emerged; C57BL/6 mice were more accurate than DBA/2 mice with stimuli of 2, 1 and 0.5s. DBA/2 mice also made more anticipatory (impulsive) responses during inter-trial intervals than C57BL/6 mice at SD of 5, 2, 1 and 0.5s. The ability to carry out the task was present in both strains of mice but they differed significantly in the levels of performance that were achieved. It is argued that the differences in accuracy and anticipatory responding were closely related and that the primary difference between the strains may be in impulsivity.
在5选串行反应时任务中，对C57BL/6和DBA/2小鼠在与注意力和冲动性相关的行为表现差异进行了比较。目的是研究小鼠中可能与人类注意力缺陷多动障碍（ADHD）相关的行为过程。将雄性小鼠分组训练，使其根据随机出现在五个孔之一中的刺激光进行鼻触反应；正确反应会得到食物奖励。在训练过程中，刺激持续时间（SD）从60秒逐渐减少到0.5秒。在训练早期，当注意力要求较低（SD为60、10或5秒）时，C57BL/6和DBA/2小鼠没有差异。随着任务要求的增加，品系差异出现了；对于2、1和0.5秒的刺激，C57BL/6小鼠比DBA/2小鼠更准确。在SD为5、2、1和0.5秒时，DBA/2小鼠在试验间隔期间也比C57BL/6小鼠做出更多的预期（冲动）反应。两种品系的小鼠都具备执行该任务的能力，但它们在完成任务的表现水平上有显著差异。有人认为，准确性和预期反应的差异密切相关，品系之间的主要差异可能在于冲动性。
