Kararizou E, Karandreas N, Davaki P, Davou R, Vassilopoulos D
Section of Neuropathology, Neurological Clinic of University of Athens, Aeginition Hospital, 72-74, Vass. Sofias Avenue, 11528 Athens, Greece.
Neuromuscul Disord. 2006 May;16(5):304-7. doi: 10.1016/j.nmd.2006.03.001. Epub 2006 Apr 17.
The aim of the present study was to investigate the causes of polyneuropathy in teenagers and to describe some characteristic clinical, laboratory, electrophysiological and pathological features. Forty-five patients with peripheral nervous disorders aged 13-19 were studied. Hereditary polyneuropathy of different types was diagnosed in 28 patients (62%); nine showed chronic inflammatory demyelinating polyneuropathy (CIDP) and two showed vasculitic neuropathy. In two more cases polyneuropathy was attributed to toxic agents, while among the rest, one was diagnosed as metachromatic leucodystrophy (juvenile type), one as adrenoleucodystrophy, one as porphyric neuropathy and one as Fabry disease. The high incidence of hereditary neuropathies in teenagers differs from that in adults, but is similar to that encountered in children. In our study, CIDP appears to be a frequent cause of neuropathy in teenagers, while the other causes are broadly similar to those found in studies concerning children rather than adults.
本研究的目的是调查青少年多发性神经病的病因，并描述一些特征性的临床、实验室、电生理和病理特征。对45例年龄在13至19岁的周围神经疾病患者进行了研究。28例患者（62%）被诊断为不同类型的遗传性多发性神经病；9例表现为慢性炎症性脱髓鞘性多发性神经病（CIDP），2例表现为血管炎性神经病。另外2例多发性神经病归因于有毒物质，其余患者中，1例被诊断为异染性脑白质营养不良（青少年型），1例为肾上腺脑白质营养不良，1例为卟啉性神经病，1例为法布里病。青少年遗传性神经病的高发病率与成年人不同，但与儿童相似。在我们的研究中，CIDP似乎是青少年神经病的常见病因，而其他病因与儿童而非成人研究中发现的病因大致相似。
