Wirtz-Peitz Frederik, Knoblich Juergen A
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
Trends Cell Biol. 2006 May;16(5):234-41. doi: 10.1016/j.tcb.2006.03.006. Epub 2006 Apr 17.
Cell polarization requires the segregation of the plasma membrane into domains of distinct protein composition. The Lethal giant larvae (Lgl) protein of Drosophila, initially identified as a tumor suppressor, establishes such domains by localizing specific proteins to specific regions of the plasma membrane. However, how it does this remains puzzling and controversial. Recent studies of the yeast orthologs show a molecular pathway through which Lgl is activated locally to promote the targeted fusion of vesicles with the plasma membrane. Here, we reconcile these data with conflicting findings on the mechanism of Lgl in animals and consider if a similar model explains its role in epithelial polarity and asymmetric cell division.
细胞极化需要将质膜分隔成具有不同蛋白质组成的区域。果蝇的致死巨幼虫（Lgl）蛋白最初被鉴定为一种肿瘤抑制因子，它通过将特定蛋白质定位到质膜的特定区域来建立这些区域。然而，它是如何做到这一点的仍然令人困惑且存在争议。最近对酵母同源物的研究揭示了一条分子途径，通过该途径Lgl被局部激活，以促进囊泡与质膜的靶向融合。在这里，我们将这些数据与关于动物中Lgl机制的相互矛盾的发现进行协调，并思考类似的模型是否能解释其在上皮极性和不对称细胞分裂中的作用。
