血管平滑肌细胞中的活性氧信号传导
Reactive oxygen species signaling in vascular smooth muscle cells.
作者信息
Clempus Roza E, Griendling Kathy K
机构信息
Department of Medicine, Division of Cardiology, Emory University, 319 WMB, 1639 Pierce Dr. Atlanta, GA 30322, USA.
出版信息
Cardiovasc Res. 2006 Jul 15;71(2):216-25. doi: 10.1016/j.cardiores.2006.02.033. Epub 2006 Mar 7.
Abstract
Reactive oxygen species (ROS) have been shown to function as important signaling molecules in the cardiovascular system. Vascular smooth muscle cells (VSMCs) contain several sources of ROS, among which the NADPH oxidases are predominant. In VSMCs, ROS mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines, as well as physiological processes, such as differentiation, by direct and indirect effects at multiple signaling levels. Therefore, it becomes critical to understand the different roles ROS play in the physiology and pathophysiology of VSMCs.
摘要
活性氧（ROS）已被证明在心血管系统中作为重要的信号分子发挥作用。血管平滑肌细胞（VSMC）含有多种ROS来源，其中NADPH氧化酶占主导地位。在VSMC中，ROS通过在多个信号水平上的直接和间接作用介导许多病理生理过程，如生长、迁移、凋亡和炎症细胞因子的分泌，以及生理过程，如分化。因此，了解ROS在VSMC的生理和病理生理中所起的不同作用变得至关重要。
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