Allgayer Heike
Department of Experimental Surgery and Molecular Oncology, Klinikum Mannheim, Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer 1-3, 68135 Mannheim, Germany.
Eur J Cancer. 2006 May;42(7):811-9. doi: 10.1016/j.ejca.2006.01.018. Epub 2006 Apr 17.
This review provides a summary of the European Association for Cancer Research Award Lecture, presented at the ECCO13 meeting in Paris in November 2005. It is a brief overview on the biological and clinical relevance of the urokinase receptor (u-PAR), an essential molecule to promote invasive and metastatic tumour phenotype and shown to be associated with early relapse and poor prognosis in many different types of cancers. The review summarizes the most important transcriptional mechanisms regulating u-PAR gene, and will focus on the differential binding of transcription factors to u-PAR promoter elements from studies in resected tumour and normal tissues of colorectal and gastric cancer patients. These studies conducted by our group may help to understand transcriptional mechanisms, which are employed to promote invasion and metastasis, in subpopulations of cancer patients. Such studies could lead to a more target-oriented patient selection and therapy against transcriptional and oncogeneic regulators in cancer.
本综述总结了2005年11月在巴黎举行的欧洲癌症研究协会奖讲座，该讲座在ECCO13会议上发表。这是对尿激酶受体（u-PAR）生物学和临床相关性的简要概述，u-PAR是促进肿瘤侵袭和转移表型的关键分子，在许多不同类型的癌症中显示与早期复发和不良预后相关。本综述总结了调节u-PAR基因的最重要转录机制，并将重点关注转录因子与结直肠癌和胃癌患者切除肿瘤及正常组织研究中u-PAR启动子元件的差异结合。我们小组进行的这些研究可能有助于理解癌症患者亚群中用于促进侵袭和转移的转录机制。此类研究可能会带来更具针对性的患者选择以及针对癌症转录和致癌调节因子的治疗方法。
