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作为核受体配体多模板的二苯甲烷骨架：法尼醇X受体和过氧化物酶体增殖物激活受体配体的制备

Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.

作者信息

Kainuma Masahiko, Kasuga Jun-ichi, Hosoda Shinnosuke, Wakabayashi Ken-ichi, Tanatani Aya, Nagasawa Kazuo, Miyachi Hiroyuki, Makishima Makoto, Hashimoto Yuichi

机构信息

Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

出版信息

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3213-8. doi: 10.1016/j.bmcl.2006.03.075. Epub 2006 Apr 17.

DOI:10.1016/j.bmcl.2006.03.075
PMID:16617018
Abstract

Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor alpha (PPARalpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.

摘要

通过使用二苯甲烷骨架替代甾体骨架，获得了新型强效法尼醇X受体（FXR）和过氧化物酶体增殖物激活受体α（PPARα）激动剂。

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