钙动力学模型中的一种缓冲肌浆网钙ATP酶泵
A buffering SERCA pump in models of calcium dynamics.
作者信息
Higgins Erin R, Cannell Mark B, Sneyd James
机构信息
Department of Mathematics, School of Medical Sciences, The University of Auckland, Auckland, New Zealand.
出版信息
Biophys J. 2006 Jul 1;91(1):151-63. doi: 10.1529/biophysj.105.075747. Epub 2006 Apr 14.
Abstract
Many cells use oscillations in calcium concentration to transmit messages. The oscillations largely result from an influx of calcium into the cytosol from the endoplasmic reticulum (ER), followed by an efflux of calcium from the cytosol back into the ER. The sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump pumps calcium into the ER. It binds calcium on the cytosolic side and releases it on the ER side and in the delay between binding and release, calcium is buffered by the pump. We developed a model of a buffering SERCA pump and investigated whether including this in a model of calcium oscillations has any significant effects. We found that the oscillations produced when using the SERCA pump, which does not buffer calcium, have a larger amplitude and a slightly smaller period than when using the buffering SERCA pump. We show that the buffering SERCA pump shows adaptation to a stimulus, and we demonstrate that, by using a bidirectional SERCA pump, we are able to eliminate futile cycling of calcium between the cytosol and ER when the cell is at rest.
摘要
许多细胞利用钙浓度的振荡来传递信息。这些振荡主要源于钙从内质网（ER）流入细胞质溶胶，随后钙又从细胞质溶胶回流到内质网。肌浆网/内质网钙ATP酶（SERCA）泵将钙泵入内质网。它在细胞质一侧结合钙，并在内质网一侧释放钙，在结合和释放之间的延迟过程中，钙被该泵缓冲。我们开发了一个缓冲SERCA泵的模型，并研究了将其纳入钙振荡模型是否有任何显著影响。我们发现，使用不缓冲钙的SERCA泵时产生的振荡，其振幅比使用缓冲SERCA泵时更大，周期略小。我们表明，缓冲SERCA泵表现出对刺激的适应性，并且我们证明，通过使用双向SERCA泵，当细胞处于静止状态时，我们能够消除钙在细胞质溶胶和内质网之间的无效循环。
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