MMWR Morb Mortal Wkly Rep. 2006 Apr 14;55(14):398-9.
Lymphocytic choriomeningitis virus (LCMV) is a rodent borne virus that can be transmitted to humans through exposure to rodent urine, feces, saliva, or blood. LCMV infection is often asymptomatic or mild but can cause aseptic meningitis, encephalitis, life-threatening infections in immunosuppressed persons, and severe congenital defects . In May 2005, LCMV was implicated in the deaths of three organ transplant recipients who had received organs from a common donor who had likely been infected from a pet rodent. In August 2005, the Connecticut Department of Public Health conducted surveys of hospital laboratories and infectious disease (ID) physicians in Connecticut to determine recent incidence of confirmed LCMV infection, the level of awareness of LCMV, and the frequency of LCMV testing. This report summarizes the results of those surveys, which indicate that awareness of LCMV is high among ID physicians; however, testing for LCMV is infrequent, and ID physicians might not be aware of the need to consider LCMV among the most susceptible populations even when a history of rodent contact is not initially evident. In part because of these findings, LCMV infection is now a physician- and laboratory-reportable disease in Connecticut. More systematic efforts are needed to determine the frequency of LCMV infection and to monitor for pet rodent infection.
淋巴细胞性脉络丛脑膜炎病毒（LCMV）是一种由啮齿动物传播的病毒，可通过接触啮齿动物的尿液、粪便、唾液或血液传播给人类。LCMV感染通常无症状或症状轻微，但可导致无菌性脑膜炎、脑炎，在免疫抑制人群中可引发危及生命的感染，以及严重的先天性缺陷。2005年5月，LCMV与三名器官移植受者的死亡有关，这些受者接受了来自一名共同供体的器官，该供体可能因宠物啮齿动物感染。2005年8月，康涅狄格州公共卫生部对该州的医院实验室和传染病医生进行了调查，以确定近期确诊的LCMV感染发病率、对LCMV的认知水平以及LCMV检测频率。本报告总结了这些调查结果，结果表明传染病医生对LCMV的认知度较高；然而，LCMV检测并不常见，即使最初没有明显的啮齿动物接触史，传染病医生可能也没有意识到在最易感人群中考虑LCMV感染的必要性。部分由于这些调查结果，LCMV感染现在在康涅狄格州成为一种需医生和实验室报告的疾病。需要更系统的努力来确定LCMV感染的频率并监测宠物啮齿动物感染情况。
