Radikova Z, Penesova A, Cizmarova E, Huckova M, Kvetnansky R, Vigas M, Koska J
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
J Hum Hypertens. 2006 Jul;20(7):510-6. doi: 10.1038/sj.jhh.1002026. Epub 2006 Apr 13.
Essential hypertension is associated with changes in central catecholaminergic pathways which might also be reflected in the pituitary response to stress stimuli. The aim of this study was to determine whether the response of pituitary hormones, cortisol, plasma renin activity, aldosterone and catecholamines to insulin-induced hypoglycaemia is changed in hypertension. We studied 22 young lean male patients with newly diagnosed untreated essential hypertension and 19 healthy normotensive, age- and body mass index (BMI)-matched controls. All subjects underwent an insulin tolerance test (0.1 IU insulin/kg body weight intravenously) with blood sampling before and 15, 30, 45, 60 and 90 min after insulin administration. Increased baseline levels of norepinephrine (P<0.05), increased response of norepinephrine (P<0.001) and decreased response of growth hormone (P<0.001), prolactin (P<0.001), adrenocorticotropic hormone (P<0.05) and cortisol (P<0.001) were found in hypertensive patients when compared to normotensive controls. Increased norepinephrine levels and a decreased pituitary response to metabolic stress stimuli may represent another manifestation of chronically increased sympathetic tone in early hypertension.
原发性高血压与中枢儿茶酚胺能通路的变化有关，这也可能反映在垂体对应激刺激的反应中。本研究的目的是确定高血压患者垂体激素、皮质醇、血浆肾素活性、醛固酮和儿茶酚胺对胰岛素诱导的低血糖的反应是否发生改变。我们研究了22名新诊断的未经治疗的原发性高血压年轻瘦男性患者和19名年龄及体重指数（BMI）匹配的健康血压正常对照者。所有受试者均接受胰岛素耐量试验（静脉注射0.1 IU胰岛素/kg体重），在注射胰岛素前及注射后15、30、45、60和90分钟进行采血。与血压正常的对照组相比，高血压患者去甲肾上腺素的基线水平升高（P<0.05），去甲肾上腺素的反应增强（P<0.001），生长激素（P<0.001）、催乳素（P<0.001）、促肾上腺皮质激素（P<0.05）和皮质醇（P<0.001）的反应减弱。去甲肾上腺素水平升高和垂体对代谢应激刺激的反应减弱可能代表早期高血压中慢性交感神经张力增加的另一种表现。
