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BAFF and APRIL as osteoclast-derived survival factors for myeloma cells: a rationale for TACI-Fc treatment in patients with multiple myeloma.

作者信息

Abe M, Kido S, Hiasa M, Nakano A, Oda A, Amou H, Matsumoto T

出版信息

Leukemia. 2006 Jul;20(7):1313-5. doi: 10.1038/sj.leu.2404228. Epub 2006 Apr 13.

DOI:10.1038/sj.leu.2404228
PMID:16617317
Abstract
摘要

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BAFF and APRIL as osteoclast-derived survival factors for myeloma cells: a rationale for TACI-Fc treatment in patients with multiple myeloma.BAFF和APRIL作为破骨细胞衍生的骨髓瘤细胞存活因子：多发性骨髓瘤患者TACI-Fc治疗的理论依据
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2
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3
Atacicept (TACI-Ig) inhibits growth of TACI(high) primary myeloma cells in SCID-hu mice and in coculture with osteoclasts.阿他西普（TACI-Ig）可抑制重症联合免疫缺陷（SCID）-人源化小鼠体内TACI（高表达）原发性骨髓瘤细胞的生长，并抑制其与破骨细胞共培养时的生长。
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BAFF, APRIL and their receptors: structure, function and signaling.B细胞活化因子、增殖诱导配体及其受体：结构、功能与信号传导
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Travelling with the BAFF/BLyS family: are we there yet?与BAFF/BLyS家族同行：我们到了吗？
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TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice.TACI:Fc 清除B细胞活化因子（BAFF）可减轻卵清蛋白诱导的小鼠支气管哮喘。
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Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development.脂肪细胞作为免疫细胞：在正常和病理性脂肪组织发育的不同阶段，肿瘤坏死因子样弱凋亡诱导因子（TWEAK）、B细胞活化因子（BAFF）和增殖诱导配体（APRIL）及其受体（Fn14、BAFF-R、跨膜激活剂和钙调亲环素配体相互作用分子（TACI）以及B细胞成熟抗原（BCMA））的差异表达
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APRIL and BAFF proteins increase proliferation of human adipose-derived stem cells through activation of Erk1/2 MAP kinase.APRIL 和 BAFF 蛋白通过激活 Erk1/2 MAP 激酶促进人脂肪来源干细胞的增殖。
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APRIL is overexpressed in cancer: link with tumor progression.增殖诱导配体（APRIL）在癌症中过度表达：与肿瘤进展的关联。
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The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature.骨髓瘤细胞中TACI基因的表达水平与微环境依赖性特征和浆母细胞特征相关。
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Molecular Crosstalk between Chromatin Remodeling and Tumor Microenvironment in Multiple Myeloma.染色质重塑与多发性骨髓瘤肿瘤微环境的分子串扰。
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