Yin Hong-fang, Li Ting
Department of Pathology, Peking University First Hospital, Beijing 100034, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2006 Apr 18;38(2):189-92.
To assess the expression of specific virulence-associated Helicobacter pylori (Hp) genotypes. (cag A, vac A, and ice A status) in primary gastrointestinal B cell lymphoma.
Forty-nine paraffin wax embedded tissues were analyzed by immunohistochemical staining and polymerase chain reaction.
There were 14 cases of mucosa associated lymphoid tissue lymphoma (MALT-L) (8 in stomach, and 6 in intestine) and 35 cases of diffuse large B cell lymphoma (DLBCL) (21 in stomach, and 14 in intestine) in all. The positive rates of vac A s1, vac A s2, vac A m2, ice A 1 and cag A were 50.0%, 42.9%, 50.0%, 14.3% and 85.7% in MALT-L; 57.1%, 40.0%, 25.7%, 5.7% and 91.4% in DLBCL, respectively.
High toxicity cag A+Hp strains seem to play a role in the pathogenesis of gastrointestinal B cell lymphoma, whereas vac A m2 may be more associated with MALT-L. Clinical stage was not associated with virulence-associated Hp genotypes.
评估原发性胃肠道B细胞淋巴瘤中幽门螺杆菌（Hp）特定毒力相关基因型（cagA、vacA和iceA状态）的表达情况。
采用免疫组织化学染色和聚合酶链反应对49例石蜡包埋组织进行分析。
共14例黏膜相关淋巴组织淋巴瘤（MALT-L）（胃8例，肠6例）和35例弥漫性大B细胞淋巴瘤（DLBCL）（胃21例，肠14例）。MALT-L中vacA s1、vacA s2、vacA m2、iceA 1和cagA的阳性率分别为50.0%、42.9%、50.0%、14.3%和85.7%；DLBCL中分别为57.1%、40.0%、25.7%、5.7%和91.4%。
高毒力cagA + Hp菌株似乎在胃肠道B细胞淋巴瘤的发病机制中起作用，而vacA m2可能与MALT-L更相关。临床分期与毒力相关的Hp基因型无关。
