Cović Dinko, Ivanković Sinisa, Hirsl Nevenka, Rupcić Boris, Samija Mirko, Jurin Mislav
University Hospital for Tumors, Department of Radiation Oncology, Zagreb, Croatia.
Coll Antropol. 2006 Mar;30(1):185-9.
The dynamics of SCCVII transplantable tumor growth in C3H/H mice was determined after local tumor irradiation and/or virus (NDV LaSota) i.p. injection. The virus applied alone significantly suppressed tumor growth, particularly until the 19th day after tumor transplantation. Local irradiation with 30 Gy resulted in tumor disappearance followed with its regrowth about 15 days later. However, if the virus was injected after the irradiation, there was no tumor growth until the end of the 31 day observation period. It should be noted that virus application prior to local irradiation did not have any additional influence on tumor growth. Thus, the pronounced efficacy of virus applied after tumor irradiation deserves attention. It is possible that the virus injected after irradiation induced a chain of cytokine production joining the action of tumor destruction induced by irradiation. This should be further studied in clarifying the approaches to combined tumor therapy with possible cell-free vaccine production.
在对C3H/H小鼠的SCCVII可移植肿瘤进行局部肿瘤照射和/或腹腔注射病毒（新城疫病毒LaSota）后，测定了肿瘤生长动力学。单独应用病毒可显著抑制肿瘤生长，尤其是在肿瘤移植后的第19天之前。30 Gy的局部照射导致肿瘤消失，约15天后肿瘤重新生长。然而，如果在照射后注射病毒，在31天观察期结束前均无肿瘤生长。应当指出，在局部照射前应用病毒对肿瘤生长没有任何额外影响。因此，肿瘤照射后应用病毒的显著疗效值得关注。照射后注射的病毒可能诱导了一系列细胞因子的产生，协同照射诱导的肿瘤破坏作用。这一点应在进一步阐明联合肿瘤治疗方法及可能的无细胞疫苗生产方面进行深入研究。
