Tomkowicz Aneta, Kraus-Filarska Maria
Akademia Medyczna we Wrocławiu, Katedra i Klinika Chorób Wewnetrznych i Alergologii.
Pol Merkur Lekarski. 2006 Jan;20(115):99-103.
Asthma is a chronic inflammatory disease of the airways. Structural alteration of the airways and lung parenchyma, "remodeling", is a recognized feature of chronic asthma and a cause of irreversible airway obstruction. Airway and lung remodeling in asthma involves subepithelial fibrosis, but also alterations of bronchial epithelium, airway smooth muscle cells, myofibroblasts, extracellular matrix, mucous glands, blood vessels and nerves. Defining of morphological changes and correlating them with clinical features of the disease has been a major focus of research over the past decade. The results of these studies are often contradictory and there is still little understanding of the mechanisms underlying lung remodeling in asthma.
哮喘是一种气道慢性炎症性疾病。气道和肺实质的结构改变，即“重塑”，是慢性哮喘的一个公认特征，也是不可逆气道阻塞的一个原因。哮喘中的气道和肺重塑涉及上皮下纤维化，还包括支气管上皮、气道平滑肌细胞、肌成纤维细胞、细胞外基质、黏液腺、血管和神经的改变。在过去十年中，确定形态学变化并将其与该疾病的临床特征相关联一直是研究的主要重点。这些研究的结果往往相互矛盾，对哮喘中肺重塑的潜在机制仍知之甚少。
