Skretkowicz Jadwiga, Skretkowicz-Szarmach Kamila
Uniwersytet Medyczny w Lodzi: Zakład Farmakogenetyki.
Pol Merkur Lekarski. 2006 Jan;20(115):117-20.
Systemic sclerosis (SSc) is chronic autoimmune disease that may affect many organs. Genetic and environmental factors are implicated in the pathogenesis of SSc. Systemic sclerosis prevalence is connected with sex, autoimmune diseases or phenomena, several ethnic groups and families. In this study we describe numerous genetic phenomena that may be implicated in the etiopathogenesis of SSc. i.e. antigens of major histocompatibility complex, microchimerism, polymorphism of several genes coding extracellular matrix components, receptors, adhesion molecules and cytokines. Genetic background plays an important role in this disorder and is connected with multiple genes.
系统性硬化症（SSc）是一种可能影响多个器官的慢性自身免疫性疾病。遗传和环境因素与SSc的发病机制有关。系统性硬化症的患病率与性别、自身免疫性疾病或现象、几个种族群体和家族有关。在本研究中，我们描述了许多可能与SSc的病因发病机制有关的遗传现象，即主要组织相容性复合体的抗原、微嵌合体、编码细胞外基质成分、受体、黏附分子和细胞因子的多个基因的多态性。遗传背景在这种疾病中起着重要作用，并且与多个基因相关。
