[Genetics in systemic sclerosis].

Systemic sclerosis (SSc) is chronic autoimmune disease that may affect many organs. Genetic and environmental factors are implicated in the pathogenesis of SSc. Systemic sclerosis prevalence is connected with sex, autoimmune diseases or phenomena, several ethnic groups and families. In this study we describe numerous genetic phenomena that may be implicated in the etiopathogenesis of SSc. i.e. antigens of major histocompatibility complex, microchimerism, polymorphism of several genes coding extracellular matrix components, receptors, adhesion molecules and cytokines. Genetic background plays an important role in this disorder and is connected with multiple genes.