Nagashima Osamu, Tajima Ken, Ito Jun, Kajiyama Yuichiro, Shimanuki Yuri, Miura Kayo, Sato Kouichi, Miyamoto Hideaki, Uekusa Toshikimi, Suzuki Tsutomu, Takahashi Kazuhisa, Fukuchi Yoshinosuke
Department of Respiratory Medicine, Juntendo University School of Medicine.
Nihon Kokyuki Gakkai Zasshi. 2006 Mar;44(3):215-9.
A 51-year-old man underwent left upper lobectomy due to pulmonary adenocarcinoma (cT2N1M0, stage IIB) in August, 2003. Since he turned out pT2N3M0 stage IIIB, he received combination chemotherapy with carboplatin and gemcitabine. During a second course chemotherapy, he was admitted again because of dyspnea and the deterioration of diffuse interstitial shadows in both lungs. He was treated with various antibiotics and corticosteroids. Unfortunately, he could not recover. An autopsy was performed. Microscopic features of the lung revealed diffuse alveolar damage and pulmonary hemorrhage. In this case, pulmonary hemorrhage should be considered as a complication of gemcitabine-induced lung injury.
一名51岁男性于2003年8月因肺腺癌（cT2N1M0，IIB期）接受了左上叶切除术。由于术后病理结果为pT2N3M0 IIIB期，他接受了卡铂和吉西他滨的联合化疗。在第二个疗程化疗期间，他因呼吸困难和双肺弥漫性间质阴影恶化再次入院。他接受了多种抗生素和皮质类固醇治疗。不幸的是，他未能康复。进行了尸检。肺部的微观特征显示为弥漫性肺泡损伤和肺出血。在这种情况下，肺出血应被视为吉西他滨诱导的肺损伤的一种并发症。
