Sakai Yasuyuki, Fujii Yasuhisa, Hyochi Nobuhiko, Masuda Hitoshi, Kawakami Satoru, Kobayashi Tsuyoshi, Kageyama Yukio, Kihara Kazunori
The Department of Urology, Graduate School, Tokyo Medical and Dental University.
Hinyokika Kiyo. 2006 Mar;52(3):173-5.
A previous study indicated that distilled water could prevent bladder tumor cell implantation in an in vitro assay. We investigated whether a large amount of distilled water irrigation prevented recurrence of superficial bladder cancer in the clinical setting and then we estimated whether cancer cell implantation at the time of transurethral resection is a major mechanism of recurrence. Between May 2000 and January 2002, 22 patients with primary, superficial bladder carcinoma who underwent transurethral resection of bladder tumors (TURBT) were enrolled in this study. The patients underwent bladder washout with 1,000 ml distilled water immediately after TURBT, and then intravesical irrigation with 3,000 ml water for three hours. Control patients were randomly chosen from those who previously underwent TURBT in our hospital and had similar prognostic factors. The 1- and 2-year recurrence-free rates in the patients undergoing distilled water irrigation were both 45% and those in the control patients were 65% and 45%, respectively. There were no significant differences between the two groups. This result indicates that distilled water was ineffective in preventing recurrence of superficial bladder tumor.
先前的一项研究表明，在体外试验中蒸馏水可防止膀胱肿瘤细胞种植。我们调查了在临床环境中大量蒸馏水冲洗是否能预防浅表性膀胱癌的复发，然后评估经尿道切除时癌细胞种植是否为复发的主要机制。在2000年5月至2002年1月期间，22例原发性浅表性膀胱癌患者接受了经尿道膀胱肿瘤切除术（TURBT）并纳入本研究。患者在TURBT后立即用1000毫升蒸馏水进行膀胱冲洗，然后用3000毫升水进行膀胱内灌注3小时。对照患者从我院先前接受TURBT且具有相似预后因素的患者中随机选取。接受蒸馏水灌注的患者1年和2年无复发生存率均为45%，对照患者分别为65%和45%。两组之间无显著差异。该结果表明蒸馏水在预防浅表性膀胱肿瘤复发方面无效。
