Lu B, Lee J M, Elliott R, Dreyfus C F, Adler J E, Black I B
Department of Neurology, Cornell University of Medical College, New York, NY 10021.
Brain Res Mol Brain Res. 1991 Oct;11(3-4):359-62. doi: 10.1016/0169-328x(91)90046-z.
Nerve growth factor (NGF) gene expression in central nervous system (CNS) glia appears to be associated with active glial growth. To study the underlying molecular mechanisms, we examined the effects of a number of growth-related factors on NGF mRNA expression in glial cultures. Our results suggest that glial membrane interaction, as a consequence of growth, actively inhibits NGF gene expression in CNS glia.
中枢神经系统（CNS）神经胶质细胞中的神经生长因子（NGF）基因表达似乎与活跃的神经胶质生长相关。为了研究潜在的分子机制，我们检测了多种生长相关因子对神经胶质培养物中NGF mRNA表达的影响。我们的结果表明，作为生长的结果，神经胶质膜相互作用会主动抑制中枢神经系统神经胶质细胞中的NGF基因表达。
