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用于旁观者效应和基因组不稳定性实验的238Puα粒子辐照器的设计、能谱测量与模拟

Design, spectrum measurements and simulations for a 238Pu alpha-particle irradiator for bystander effect and genomic instability experiments.

作者信息

Hakanen Arvi, Siiskonen Teemu, Pöllänen Roy, Kosunen Antti, Turunen Asko, Belyakov Oleg

机构信息

STUK-Radiation and Nuclear Safety Authority P. O. Box 14, FIN-00881 Helsinki, Finland.

出版信息

Appl Radiat Isot. 2006 Aug;64(8):864-7. doi: 10.1016/j.apradiso.2006.02.097. Epub 2006 Apr 18.

DOI:10.1016/j.apradiso.2006.02.097
PMID:16618543
Abstract

Design, spectrum measurements and simulations for an alpha-particle irradiator for bystander effect and genomic instability experiments are presented. Measured alpha-particle energy spectra were used to confirm the characteristics of the source of the irradiator specified by the manufacturer of the source. The spectra were measured in vacuum with a high-resolution spectrometer and simulated with an AASI Monte Carlo code. As a next step, we simulated alpha-particle energy spectra at the target plane of the irradiator for three different source-to-target distances. In these simulations, helium was used as the medium between the source and the exit window of the irradiator; its pressure and temperature corresponded to those of the ambient air. Mean energies and full-widths at half-maximum (FWHM) were calculated for the three different helium gas tracks.

摘要

本文介绍了用于旁观者效应和基因组不稳定性实验的α粒子辐照器的设计、能谱测量和模拟。测量的α粒子能谱用于确认源制造商指定的辐照器源的特性。这些能谱是在真空中用高分辨率光谱仪测量的,并使用AASI蒙特卡罗代码进行模拟。下一步,我们针对三种不同的源到靶距离,模拟了辐照器靶平面处的α粒子能谱。在这些模拟中,氦气被用作源与辐照器出射窗之间的介质;其压力和温度与环境空气的压力和温度相对应。计算了三种不同氦气轨迹的平均能量和半高宽(FWHM)。

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