Locke Dona E C, Berry David T R, Fakhoury Toufic A, Schmitt Frederick A
Department of Psychology, University of Kentucky, Lexington, KY, USA.
J Clin Exp Neuropsychol. 2006 Apr;28(3):325-40. doi: 10.1080/13803390490918183.
Previous research suggests epilepsy and psychogenic non-epileptic seizure (PNES) patients do not show consistent group differences on neuropsychological measures. However, both groups of patients show decreased neuropsychological performance when compared to a normal population (Cragar, Berry, Fakhoury, Cibula, & Schmitt, 2002). Swanson, Springer, Benbadis, and Morris (2000) have suggested epilepsy patients show decreased neurocognitive functioning due to neuropathology whereas PNES patients show decreased neurocognitive functioning due to psychopathology. Effort has also been implicated as an important factor in neuropsychological test results in general (Green, 2003). The purpose of this study was to investigate the relationships of medical history variables (e.g., duration of disorder), neuropathology, psychopathology, and effort to neuropsychological findings in epilepsy and PNES patients. Neuropsychological functioning was divided into six domains: intelligence, memory, language, executive functions, visual-spatial, and motor. Results indicated that medical history variables were related to intellectual, memory, language, and motor functioning. Psychopathology was associated with all cognitive domains except executive functioning. Effort was related to intellectual, memory, language, visual-spatial, and motor functioning. Neuropathology and diagnosis were related only to memory.
先前的研究表明，癫痫患者和精神性非癫痫性发作（PNES）患者在神经心理学测量上并未表现出一致的组间差异。然而，与正常人群相比，这两组患者的神经心理学表现均有所下降（克拉加、贝里、法胡里、西布拉和施密特，2002年）。斯旺森、斯普林格、本巴迪斯和莫里斯（2000年）提出，癫痫患者由于神经病理学原因导致神经认知功能下降，而PNES患者则由于精神病理学原因导致神经认知功能下降。一般来说，努力程度也被认为是神经心理学测试结果中的一个重要因素（格林，2003年）。本研究的目的是调查病史变量（如疾病持续时间）、神经病理学、精神病理学以及努力程度与癫痫患者和PNES患者神经心理学结果之间的关系。神经心理学功能分为六个领域：智力、记忆、语言、执行功能、视觉空间和运动。结果表明，病史变量与智力、记忆、语言和运动功能有关。精神病理学与除执行功能外的所有认知领域相关。努力程度与智力、记忆、语言、视觉空间和运动功能有关。神经病理学和诊断仅与记忆有关。
