Crosnier Cécile, Stamataki Despina, Lewis Julian
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Nat Rev Genet. 2006 May;7(5):349-59. doi: 10.1038/nrg1840.
The lining of the intestine is renewed at an extraordinary rate, outpacing all other tissues in the vertebrate body. The renewal process is neatly organized in space, so that the whole production line, from the ever-youthful stem cells to their dying, terminally differentiated progeny, is laid out to view in histological sections. A flurry of recent papers has clarified the key regulatory signals and brought us to the point where we can begin to give a coherent account, for at least one tissue, of how these signals collaborate to organize the architecture and behaviour of a stem-cell system.
肠道内壁以极快的速度更新，超过了脊椎动物体内的所有其他组织。更新过程在空间上组织得井井有条，以至于在组织切片中可以看到整个生产线，从永葆青春的干细胞到它们濒死的终末分化后代。最近的一系列论文阐明了关键的调控信号，使我们能够开始连贯地解释，至少对于一种组织而言，这些信号是如何协同作用来构建干细胞系统的结构和调控其行为的。
