Wilson Andrew A, Kotton Darrell N
Boston University School of Medicine, Boston, MA 02118, USA.
Bioessays. 2008 Feb;30(2):107-9. doi: 10.1002/bies.20710.
Previous work has suggested that many stem cells can be found in microanatomic niches, where adjacent somatic cells of the niche control the differentiation and proliferation states of their resident stem cells. Recently published work examining intestinal stem cells (ISCs) in the adult Drosophila midgut suggests a new paradigm where some stem cells actively control the cell fate decisions of their daughters. Here, we review recent literature((1)) demonstrating that, in the absence of a detectable stem cell niche, multipotent Drosophila ISCs modulate the Notch signaling pathway in their adjacent daughter cells in order to specify the differentiated lineages of their descendants. These observations made in Drosophila are challenging and advancing our understanding of stem cell biology.
先前的研究表明，许多干细胞存在于微解剖龛中，龛中的相邻体细胞控制着其驻留干细胞的分化和增殖状态。最近发表的一项关于成年果蝇中肠肠道干细胞（ISC）的研究提出了一种新的模式，即一些干细胞会主动控制其后代细胞的命运决定。在这里，我们回顾了最近的文献（(1)），这些文献表明，在没有可检测到的干细胞龛的情况下，多能性果蝇ISC会调节其相邻子代细胞中的Notch信号通路，以确定其后代的分化谱系。在果蝇中所做的这些观察具有挑战性，并正在推动我们对干细胞生物学的理解。
