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非免疫抑制患者中枢神经系统隐球菌病的预后较差：呼吁更好地识别疾病并评估抗真菌治疗辅助手段。

The poor prognosis of central nervous system cryptococcosis among nonimmunosuppressed patients: a call for better disease recognition and evaluation of adjuncts to antifungal therapy.

作者信息

Ecevit Ismail Zafer, Clancy Cornelius J, Schmalfuss Ilona M, Nguyen M Hong

机构信息

Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA.

出版信息

Clin Infect Dis. 2006 May 15;42(10):1443-7. doi: 10.1086/503570. Epub 2006 Apr 11.

DOI:10.1086/503570
PMID:16619158
Abstract

We describe 9 nonimmunosuppressed patients with central nervous system cryptococcosis. Morbidity and mortality were high, especially among patients with cerebral infarcts. This was attributed to delayed diagnosis and apparent sequelae of overwhelming host immune responses. We present clues suggesting the diagnosis. Increased recognition and timely diagnosis of this condition may improve outcomes.

摘要

我们描述了9例非免疫抑制的中枢神经系统隐球菌病患者。发病率和死亡率很高，尤其是在脑梗死患者中。这归因于诊断延迟以及宿主免疫反应过度的明显后遗症。我们提出了有助于诊断的线索。提高对这种疾病的认识并及时诊断可能会改善预后。

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