Pawar Sachin S, Panepinto Julie A, Brousseau David C
Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Pediatr Blood Cancer. 2008 Jan;50(1):111-3. doi: 10.1002/pbc.20872.
Exhaled nitric oxide (FE(NO)) has been shown to be decreased in children with sickle cell disease. We sought to evaluate the effect of sickle cell vaso-occlusive crisis (VOC) on FE(NO) levels. We measured FE(NO) levels in 42 children with sickle cell disease, 29 in their baseline health and 13 during an acute VOC. There was no difference in FE(NO) levels between children at baseline (15.12 +/- 9.32 ppb) and those during an acute VOC (15.68 +/- 7.26 ppb; P = 0.794). FE(NO) is not a useful marker of acute VOC in children with sickle cell disease.
已证明患有镰状细胞病的儿童呼出一氧化氮（FE(NO)）水平会降低。我们试图评估镰状细胞血管闭塞性危机（VOC）对FE(NO)水平的影响。我们测量了42名镰状细胞病儿童的FE(NO)水平，其中29名处于基线健康状态，13名处于急性VOC期间。基线时儿童的FE(NO)水平（15.12 +/- 9.32 ppb）与急性VOC期间儿童的FE(NO)水平（15.68 +/- 7.26 ppb；P = 0.794）之间没有差异。FE(NO)并非镰状细胞病儿童急性VOC的有用标志物。
