bcl-2在子宫内膜样子宫内膜癌中的作用：一项实验研究。

Role of bcl-2 in endometrioid corpus cancer: an experimental study.

作者信息

Mariani Andrea, Sebo Thomas J, Cliby William A, Keeney Gary L, Riehle Darren L, Lesnick Timothy G, Podratz Karl C

机构信息

Division of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.

出版信息

Anticancer Res. 2006 Mar-Apr;26(2A):823-7.

PMID:16619475

Abstract

BACKGROUND

Bcl-2 expression appears to be under hormonal control in normal endometrium and to correlate with hormone receptor status in endometrial cancer. The aim of this study was to assess bcl-2 expression in endometrial cancer.

MATERIALS AND METHODS

Hysterectomy specimens from 125 patients with endometrial cancer were stained for bcl-2. Estrogen receptor (ER) and progesterone receptor (PR) levels were quantified with a dextran-coated charcoal assay.

RESULTS

Bcl-2 expression correlated significantly with endometrioid histology and high levels of ER and PR (p < 0.05). For the entire population, bcl-2 expression was not significantly associated with the presence of extrauterine disease. However, when only patients with grade 1 or 2 endometrioid histology were considered, tumors with bcl-2 expression were significantly (p < 0.05) more likely to present with extrauterine disease than those not expressing bcl-2.

CONCLUSION

Bcl-2-mediated inhibition of apoptosis may be important in the acquisition of molecular alterations and development of metastases in a subset of hormone-dependent endometrial cancers.

摘要

背景

在正常子宫内膜中，Bcl-2表达似乎受激素控制，且与子宫内膜癌中的激素受体状态相关。本研究的目的是评估子宫内膜癌中Bcl-2的表达情况。

材料与方法

对125例子宫内膜癌患者的子宫切除标本进行Bcl-2染色。采用葡聚糖包被活性炭法对雌激素受体（ER）和孕激素受体（PR）水平进行定量分析。

结果

Bcl-2表达与子宫内膜样组织学类型以及高水平的ER和PR显著相关（p < 0.05）。对于总体人群，Bcl-2表达与子宫外疾病的存在无显著相关性。然而，仅考虑组织学类型为1级或2级子宫内膜样的患者时，与不表达Bcl-2的肿瘤相比，表达Bcl-2的肿瘤出现子宫外疾病的可能性显著更高（p < 0.05）。