Mariani Andrea, Sebo Thomas J, Cliby William A, Keeney Gary L, Riehle Darren L, Lesnick Timothy G, Podratz Karl C
Division of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
Anticancer Res. 2006 Mar-Apr;26(2A):823-7.
Bcl-2 expression appears to be under hormonal control in normal endometrium and to correlate with hormone receptor status in endometrial cancer. The aim of this study was to assess bcl-2 expression in endometrial cancer.
Hysterectomy specimens from 125 patients with endometrial cancer were stained for bcl-2. Estrogen receptor (ER) and progesterone receptor (PR) levels were quantified with a dextran-coated charcoal assay.
Bcl-2 expression correlated significantly with endometrioid histology and high levels of ER and PR (p < 0.05). For the entire population, bcl-2 expression was not significantly associated with the presence of extrauterine disease. However, when only patients with grade 1 or 2 endometrioid histology were considered, tumors with bcl-2 expression were significantly (p < 0.05) more likely to present with extrauterine disease than those not expressing bcl-2.
Bcl-2-mediated inhibition of apoptosis may be important in the acquisition of molecular alterations and development of metastases in a subset of hormone-dependent endometrial cancers.
在正常子宫内膜中，Bcl-2表达似乎受激素控制，且与子宫内膜癌中的激素受体状态相关。本研究的目的是评估子宫内膜癌中Bcl-2的表达情况。
对125例子宫内膜癌患者的子宫切除标本进行Bcl-2染色。采用葡聚糖包被活性炭法对雌激素受体（ER）和孕激素受体（PR）水平进行定量分析。
Bcl-2表达与子宫内膜样组织学类型以及高水平的ER和PR显著相关（p < 0.05）。对于总体人群，Bcl-2表达与子宫外疾病的存在无显著相关性。然而，仅考虑组织学类型为1级或2级子宫内膜样的患者时，与不表达Bcl-2的肿瘤相比，表达Bcl-2的肿瘤出现子宫外疾病的可能性显著更高（p < 0.05）。
在一部分激素依赖性子宫内膜癌中，Bcl-2介导的细胞凋亡抑制可能在分子改变的获得和转移的发生中起重要作用。
