Uramoto Hidetaka, Sugio Kenji, Oyama Tsunehiro, Hanagiri Takeshi, Yasumoto Kosei
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Anticancer Res. 2006 Mar-Apr;26(2A):983-8.
p53R2 plays a crucial role in supplying dNTPs for DNA repair. The expression of p53R2 is induced by DNA-damaging agents in a p53-dependent manner and p53R2 translocates to the nucleus upon DNA damage. Immunohistochemistry was used to analyze the protein expression of p53R2 in paraffin-embedded tumor samples from 130 well-characterized non-small cell lung cancer (NSCLC) patients and the expression level of p53R2, clinical variables and survival outcome were compared. A positive expression of p53R2 was detected in the cytoplasm of tumor cells in 61 of the 130 patients (46.2%) with NSCLC. The positive ratio was significantly higher in the patients with pathological stage II/III, pathological T3-4 and pathological N1-3 than in those with stage I, T1-2 and N0, respectively. No significant difference was observed between the p53R2 expression and the gender, age at operation, histological type or p53 expression. Though our findings do not support that the p53R2 immunocytochemical marker alone plays an important prognostic role in NSCLC, the DNA repair pathway mediated by p53R2 may be responsible for controlling the growth of lung cancer.
p53R2在为DNA修复提供脱氧核糖核苷三磷酸（dNTPs）方面发挥着关键作用。p53R2的表达由DNA损伤剂以p53依赖的方式诱导，并且在DNA损伤时p53R2会转位至细胞核。采用免疫组织化学方法分析了130例特征明确的非小细胞肺癌（NSCLC）患者石蜡包埋肿瘤样本中p53R2的蛋白表达情况，并比较了p53R2的表达水平、临床变量和生存结果。在130例NSCLC患者中，有61例（46.2%）的肿瘤细胞胞质中检测到p53R2阳性表达。病理分期为II/III期、病理T3 - 4和病理N1 - 3的患者阳性率分别显著高于I期、T1 - 2和N0的患者。p53R2表达与性别、手术年龄、组织学类型或p53表达之间未观察到显著差异。虽然我们的研究结果不支持单独的p53R2免疫细胞化学标志物在NSCLC中起重要的预后作用，但由p53R2介导的DNA修复途径可能负责控制肺癌的生长。
