Utsuki Satoshi, Oka Hidehiro, Sato Sumito, Suzuki Sachio, Shimizu Satoru, Tanaka Satoshi, Fujii Kiyotaka
Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
J Neurosurg. 2006 Apr;104(4):618-20. doi: 10.3171/jns.2006.104.4.618.
The response of nonfluorescing infiltrating tumors that had been exposed to 5-aminolevulinic acid and irradiated using a laser at a wavelength of 405 nm was analyzed intraoperatively using spectroscopy. Histological analyses demonstrated that neoplastic cells were present in the tissue region that displayed a peak at 636 nm, whereas no neoplastic cells were present in the region that exhibited only the excitation light peak. The authors conclude that the intraoperative use of laser spectroscopy can allow the diagnosis of infiltrating tumor and the detection of boundaries of the infiltrate when standard fluorescence techniques fail.
对已暴露于5-氨基酮戊酸并使用波长为405 nm的激光进行照射的无荧光浸润性肿瘤的反应，在术中使用光谱学进行了分析。组织学分析表明，在显示636 nm峰值的组织区域存在肿瘤细胞，而仅表现出激发光峰值的区域不存在肿瘤细胞。作者得出结论，当标准荧光技术失效时，术中使用激光光谱学可以实现浸润性肿瘤的诊断以及浸润边界的检测。
