Amambua A N, Ghogomu S M, Tachu J B, Pelle R, Titanji V P K
Biotechnology Unit, University of Buea, Cameroon.
East Afr Med J. 2005 Dec;82(12):614-24. doi: 10.4314/eamj.v82i12.9366.
To determine the role of an immunodominant antigen OvPG-1 in human onchocerciasis.
Cross-sectional study of subjects living in three onchocerciasis endemic areas.
Mbonge and Tubah divisions of Western Cameroon and in Esmeralda Province of Ecuador.
There were 94 and 99 subjects from the Cameroon rain forest and savannah respectively, and 83 endemic residents from Ecuador.
The IgG2 anti-OvPG-1 responses of visually impaired and microfiladermic patients were significantly higher than for their age and sex matched counterparts with normal vision and no microfiladermia (p=0.024). Furthermore, the isotype specificity of anti-OvPG-I responses varied for the various onchocerciasis endemic zones. IgG1, IgG2, IgG3 and IgE levels correlated with the presence of microfilariae in Cameroon, but not in Ecuador.
Increased IgG and IgE levels to the antigen OvPG-1 seem to correlate with the development of onchocercal eye pathology. The present results suggest that the OvPG1 is a dominant antigen of Onchocerca volvulus with a significant role in the pathogenesis of onchocerciasis.
确定免疫显性抗原OvPG-1在人类盘尾丝虫病中的作用。
对生活在三个盘尾丝虫病流行区的受试者进行横断面研究。
喀麦隆西部的姆邦格和图巴赫分区以及厄瓜多尔的埃斯梅拉达省。
分别有94名和99名来自喀麦隆雨林和稀树草原的受试者，以及83名来自厄瓜多尔的流行区居民。
视力受损和有微丝蚴血症的患者的IgG2抗OvPG-1反应显著高于年龄和性别匹配的视力正常且无微丝蚴血症的对照者（p = 0.024）。此外，抗OvPG-I反应的同种型特异性在不同的盘尾丝虫病流行区有所不同。在喀麦隆，IgG1、IgG2、IgG3和IgE水平与微丝蚴的存在相关，但在厄瓜多尔则不然。
针对抗原OvPG-1的IgG和IgE水平升高似乎与盘尾丝虫性眼病的发展相关。目前的结果表明，OvPG1是盘尾丝虫的主要抗原，在盘尾丝虫病的发病机制中起重要作用。
