Musiał Witold, Kubis Aleksander
Katedra Farmacji Stosowanej, Zakład Technologii Postaci Leku we Wrocławiu.
Polim Med. 2005;35(4):51-61.
This review focuses on the colonic drug delivery, especially using biodegradable polymers i.e. guar gum, chondroitin sulfate, pectin, starch and amylose, dextran, chitosan, inulin. Basics of colon-specific targeting, formulation aspects, microflora influence and application of cross-linking techniques and polymer mixtures for targeting drugs into the colon are presented. Adventages and disadventages of colon-specific drug delivery are also described. A number of polymers is important in the context of colon-specific drug delivery. Considerable progress has been made over last three decades in this area. Although extensive investigations have to be done in the area of microflora endogenous ecosystems and enzymatic science, immunoactivity of biopolymers, and absorption enhancers for colonic mucous. Completely synthetic polymers of good swelling properties and sensitive to bacterial enzymes are also possible in the close future.
本综述聚焦于结肠给药，特别是使用可生物降解聚合物，即瓜尔胶、硫酸软骨素、果胶、淀粉和直链淀粉、葡聚糖、壳聚糖、菊粉。介绍了结肠特异性靶向的基础、制剂方面、微生物群的影响以及用于将药物靶向递送至结肠的交联技术和聚合物混合物的应用。还描述了结肠特异性药物递送的优点和缺点。许多聚合物在结肠特异性药物递送方面很重要。在过去三十年中，该领域已取得了相当大的进展。尽管在微生物群内源性生态系统和酶学、生物聚合物的免疫活性以及结肠黏液吸收促进剂等领域仍需进行大量研究。在不久的将来，具有良好溶胀性能且对细菌酶敏感的完全合成聚合物也是可能的。
