Bansal Vipin, Malviya Rishabha, Malaviya Tanya, Sharma Pramod Kumar
Research Associate, FR&D, Akums Drugs and Pharmaceuticals Ltd, Haridwar, UK, India.
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Polim Med. 2014 Apr-Jun;44(2):109-18.
This review deals with the targeting of drugs to the lower gastrointestinal tract i.e. colon. Colonic drug delivery becomes important for localized action as well as for improved systemic availability of peptide and proteins. Drugs which have absorption window in the colonic region have been targeted using different novel technologies. pH sensitive polymers and prodrug based formulation have been used for the delivery of drugs into the colon. Different natural polymers have been used successfully for the delivery of drugs into the colon. Natural polymers are less toxic, biodegradable and easily available with a wide range of molecular weight and varying chemical compositions. One of the supporting properties associated with these polymers is that natural polymers can be used as approved pharmaceutical excipient.
本综述涉及药物靶向至下胃肠道即结肠。结肠给药对于局部作用以及改善肽和蛋白质的全身可用性而言变得至关重要。在结肠区域具有吸收窗的药物已通过不同的新技术进行靶向。pH敏感聚合物和基于前药的制剂已用于将药物递送至结肠。不同的天然聚合物已成功用于将药物递送至结肠。天然聚合物毒性较小、可生物降解且易于获得，具有广泛的分子量和不同的化学组成。与这些聚合物相关的一个支持特性是天然聚合物可用作经批准的药用辅料。
