Rottmann S, Lüscher B
Abteilung Biochemie und Molekularbiologie, Institut für Biochemie, Klinikum der RWTH, Pauwelsstrasse 30, 52074 Aachen, Germany.
Curr Top Microbiol Immunol. 2006;302:63-122. doi: 10.1007/3-540-32952-8_4.
A significant body of evidence has been accumulated that demonstrates decisive roles of members of the Myc/Max/Mad network in the control of various aspects of cell behavior, including proliferation, differentiation, and apoptosis. The components of this network serve as transcriptional regulators. Mad family members, including Mad1, Mxi1, Mad3, Mad4, Mnt, and Mga, function in part as antagonists of Myc oncoproteins. At the molecular level this antagonism is reflected by the different cofactor/chromatin remodeling complexes that are recruited by Myc and Mad family members. One important function of the latter is their ability to repress gene transcription. In this review we summarize the current view of how this repression is achieved and what the consequences of Mad action are for cell behavior. In addition, we point out some of the many aspects that have not been clarified and thus leave us with a rather incomplete picture of the functions, both molecular and at the cellular level, of Mad family members.
大量证据已经积累起来，表明Myc/Max/Mad网络成员在控制细胞行为的各个方面，包括增殖、分化和凋亡中起决定性作用。该网络的组成部分作为转录调节因子发挥作用。Mad家族成员，包括Mad1、Mxi1、Mad3、Mad4、Mnt和Mga，部分作为Myc癌蛋白的拮抗剂发挥作用。在分子水平上，这种拮抗作用表现为Myc和Mad家族成员招募的不同辅因子/染色质重塑复合物。后者的一个重要功能是它们抑制基因转录的能力。在这篇综述中，我们总结了目前关于这种抑制是如何实现的以及Mad作用对细胞行为的影响的观点。此外，我们指出了许多尚未阐明的方面，因此我们对Mad家族成员在分子和细胞水平上的功能的了解相当不完整。
