Toutouzas K, Drakopoulou M, Markou V, Stougianos P, Tsiamis E, Tousoulis D, Stefanadis C
First Department of Cardiology, Athens Medical School, Hippokration Hospital, Greece.
Eur J Clin Invest. 2006 Apr;36(4):218-23. doi: 10.1111/j.1365-2362.2006.01625.x.
Recent studies have shown that patients with single vessel coronary artery disease (CAD) suffering from acute coronary syndromes (ACS) have increased coronary sinus (CS) blood temperature compared with the right atrium (RA). The aim of this study was to investigate whether there is a correlation between systemic inflammatory indexes and CS temperature and whether there is a difference in CS temperature between patients with single vs. multivessel disease. MATERIALS AND METHODS We included consecutive patients scheduled for coronary angiography for recent-onset chest pain evaluation. We measured C-reactive protein (CRP) levels in the study population. Coronary sinus and RA blood temperature measurements were performed by a 7F thermography catheter. DeltaTau was calculated by subtracting the RA from the CS blood temperature.
The study population comprised 53 patients with ACS, 25 patients with stable angina (SA) and 22 subjects without CAD (control group). DeltaTau was greater in patients with ACS and with SA compared with the control group (0.22 +/- 0.10 degrees C, 0.18 +/- 0.04 degrees C vs. 0.14 +/- 0.07 degrees C, P < 0.01 for both comparisons). The ACS group had greater DeltaTau compared with the SA group, although the difference did not reach statistical significance (P = 0.09). Eighteen (39.1%) out of 46 patients with multivessel disease had three-vessel disease and 28 (60.8%) had two-vessel disease. DeltaTau between patients with multivessel and single vessel disease was similar (0.22 +/- 0.01 degrees C, 0.19 +/- 0.01 degrees C, P = 0.17). The levels of CRP were well correlated with DeltaTau (R = 0.35b, P < 0.01).
Systemic inflammation is well correlated with CS temperature; thus, an inflammatory process could be the underlying mechanism for increased heat production from the myocardium.
近期研究表明，患有急性冠状动脉综合征（ACS）的单支冠状动脉疾病（CAD）患者，其冠状窦（CS）血温高于右心房（RA）。本研究旨在探讨全身炎症指标与CS温度之间是否存在相关性，以及单支血管病变与多支血管病变患者的CS温度是否存在差异。材料与方法：我们纳入了因近期胸痛评估而计划进行冠状动脉造影的连续患者。我们测量了研究人群中的C反应蛋白（CRP）水平。通过7F热成像导管测量冠状窦和RA血温。通过用CS血温减去RA血温来计算ΔTau。
研究人群包括53例ACS患者、25例稳定型心绞痛（SA）患者和22例无CAD的受试者（对照组）。与对照组相比，ACS患者和SA患者的ΔTau更高（分别为0.22±0.10℃、0.18±0.04℃和0.14±0.07℃，两组比较P均<0.01）。ACS组的ΔTau高于SA组，尽管差异未达到统计学意义（P = 0.09）。46例多支血管病变患者中，18例（39.1%）为三支血管病变，28例（60.8%）为两支血管病变。多支血管病变和单支血管病变患者的ΔTau相似（分别为0.22±0.01℃、0.19±0.01℃，P = 0.17）。CRP水平与ΔTau密切相关（R = 0.35b，P < 0.01）。
全身炎症与CS温度密切相关；因此，炎症过程可能是心肌产热增加的潜在机制。
