Sparing and recovery of function in spinal larval frogs (Rana catesbeiana): effect of level of transection.

Bullfrog tadpoles with cervical or midthoracic transection of the spinal cord were allowed to recover for 5 weeks, at which time axonal growth across the transection site was assessed by transport of horseradish peroxidase. Weekly behavioral tests included those for posture, spontaneous locomotion, cutaneously elicited swimming, and intersegmental coordination. Behavioral and electrophysiological assessments suggest that behavioral recovery depends, at least in part, on the growth of fibers across the transection site. Anatomical and behavioral recovery does not appear to differ with the level of spinal transection, but there was greater sparing of posture, spontaneous locomotion, and stimulus-induced locomotion in tadpoles with thoracic transection of the spinal cords.