Van Kruiningen H J, Castellano V P, Torres A, Sharpee R L
Department of Pathobiology, University of Connecticut, Storrs 06269.
J Vet Diagn Invest. 1991 Oct;3(4):293-6. doi: 10.1177/104063879100300404.
Acute and convalescent sera were collected from 8 dairy herds with classic clinical features of winter dysentery. An enzyme-linked immunosorbent assay was used to measure coronavirus antibody titers, employing calf diarrhea coronavirus as antigen. Twenty-two of the 35 animals tested (63%) showed a greater than or equal to 4-fold seroconversion. Adult cattle in all 8 herds seroconverted. These findings complement previously reported immunoperoxidase and electron microscopic evidence, suggesting an etiologic role for an enteric coronavirus in this disease.
