多瘤病毒形式的整合DNA在复制过程中的命运。
Fate of polyoma form IDNA during replication.
作者信息
Roman A, Dulbecco R
出版信息
J Virol. 1975 Jul;16(1):70-4. doi: 10.1128/JVI.16.1.70-74.1975.
Abstract
The fate of polyoma form IDNA generated during replication was investigated in resting BALB-3T3 cells. The experiments showed that there was extensive re-entry of such molecules into replication. This process took place over a period of several hours and appeared to be random. Progeny form I molecules must, therefore, spend some time in a nonreplicating pool before reinitiating replication. We propose that two factors affect the fate of progeny form IDNA. (i) The rate of reinitiation of progeny molecules is determined by the capacity of the initiation machinery. (ii) The extent of re-entry is determined by the availability of maturation proteins which divert form I from replication.
摘要
在静止的BALB-3T3细胞中研究了复制过程中产生的多瘤病毒I型DNA的命运。实验表明，此类分子大量重新进入复制过程。这一过程持续数小时，似乎是随机发生的。因此，子代I型分子在重新启动复制之前，必须在非复制池中停留一段时间。我们认为有两个因素影响子代I型DNA的命运。（i）子代分子重新启动的速率由起始机制的能力决定。（ii）重新进入的程度由使I型分子从复制中转移的成熟蛋白的可用性决定。
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