Ogasawara Toshie, Narita Chisako, Kawauchi Kiyotaka
Tokyo Women's Medical University Medical Center East, Department of Medicine, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan.
Leuk Res. 2007 Mar;31(3):403-6. doi: 10.1016/j.leukres.2006.02.029. Epub 2006 Apr 18.
We describe a 79-year-old man who had massive pleural effusion and a proliferation of prolymphocytic leukemia cells in the peripheral blood, bone marrow, and pleural effusion fluid. Immunophenotyping of leukemia cells revealed either CD3+CD4+CD8-CD25+ or CD3+CD4+CD8+CD25+. The antibody against human T-cell lymphotropic virus type I was negative. A diagnosis of T-PLL was made. The level of VEGF in the plasma or pleural effusion fluid was very high. Moreover, polymerase chain reaction analysis demonstrated an expression of VEGF mRNA in the leukemia cells, indicating a production of VEGF from leukemia cells and its involvement in the pathogenesis of T-PLL.
我们描述了一名79岁男性，其外周血、骨髓和胸腔积液中存在大量胸腔积液及幼淋巴细胞白血病细胞增殖。白血病细胞的免疫表型分析显示为CD3 + CD4 + CD8 - CD25 + 或CD3 + CD4 + CD8 + CD25 + 。抗人类I型嗜T细胞病毒抗体为阴性。诊断为T细胞幼淋巴细胞白血病（T-PLL）。血浆或胸腔积液中血管内皮生长因子（VEGF）水平非常高。此外，聚合酶链反应分析表明白血病细胞中VEGF mRNA表达，提示白血病细胞产生VEGF并参与T-PLL的发病机制。
