詹氏甲烷嗜热球菌利用一条修饰的甲羟戊酸途径来生物合成异戊烯基二磷酸。
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate.
作者信息
Grochowski Laura L, Xu Huimin, White Robert H
机构信息
Department of Biochemistry (0308), Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
出版信息
J Bacteriol. 2006 May;188(9):3192-8. doi: 10.1128/JB.188.9.3192-3198.2006.
Abstract
Archaea have been shown to produce isoprenoids from mevalonate; however, genome analysis has failed to identify several genes in the mevalonate pathway on the basis of sequence similarity. A predicted archaeal kinase, coded for by the MJ0044 gene, was associated with other mevalonate pathway genes in the archaea and was predicted to be the "missing" phosphomevalonate kinase. The MJ0044-derived protein was tested for phosphomevalonate kinase activity and was found not to catalyze this reaction. The MJ0044 gene product was found to phosphorylate isopentenyl phosphate, generating isopentenyl diphosphate. Unlike other known kinases associated with isoprene biosynthesis, Methanocaldococcus jannaschii isopentenyl phosphate kinase is predicted to be a member of the aspartokinase superfamily.
摘要
古菌已被证明可从甲羟戊酸合成类异戊二烯；然而，基因组分析未能基于序列相似性在甲羟戊酸途径中鉴定出几个基因。由MJ0044基因编码的一种预测的古菌激酶，与古菌中的其他甲羟戊酸途径基因相关联，并且被预测为“缺失的”磷酸甲羟戊酸激酶。对MJ0044衍生的蛋白质进行了磷酸甲羟戊酸激酶活性测试，发现其不催化该反应。发现MJ0044基因产物可使异戊烯基磷酸磷酸化，生成异戊烯基二磷酸。与其他已知的与异戊二烯生物合成相关的激酶不同，詹氏甲烷球菌异戊烯基磷酸激酶被预测为天冬氨酸激酶超家族的一员。
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