铁外流蛋白铁转运蛋白调节肠炎沙门氏菌的细胞内生长。
The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica.
作者信息
Chlosta Sabine, Fishman Douglas S, Harrington Lynne, Johnson Erin E, Knutson Mitchell D, Wessling-Resnick Marianne, Cherayil Bobby J
机构信息
Pediatric Gastroenterology Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
出版信息
Infect Immun. 2006 May;74(5):3065-7. doi: 10.1128/IAI.74.5.3065-3067.2006.
Abstract
We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.
摘要
我们研究了巨噬细胞铁输出蛋白铁转运蛋白及其配体铁调素对细胞内沙门氏菌生长的影响。铁转运蛋白表达升高会抑制细菌繁殖；铁调素诱导的铁转运蛋白下调则会增强细菌繁殖。对铁反应性沙门氏菌基因的表达分析表明铁转运蛋白介导了铁剥夺。这些结果证明了铁转运蛋白在抗菌抗性中的作用。
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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.铁调素通过与铁转运蛋白结合并诱导其内化来调节细胞铁外流。
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