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泰国小儿心脏手术等待时间及其对死亡率的影响:朱拉隆功大学、儿童医院和清迈大学医院的合作研究。

Pediatric heart surgery waiting time in Thailand and its effect on mortality: A cooperative study from Chulalongkorn, Children and Chiang Mai University hospitals.

作者信息

Khongphatthanayothin Apichai, Layangool Thanarat, Sittiwangkul Rekwan, Pongprot Yupada, Lertsapcharoen Pornthep, Mokarapong Pirapat

机构信息

Chulalongkorn University, Bangkok, Thailand.

出版信息

J Med Assoc Thai. 2005 Sep;88 Suppl 4:S23-9.

Abstract

BACKGROUND

Thai children who need cardiac surgery are often put on a waiting list. The waiting time and mortality during waiting have not been previously systematically studied.

MATERIAL AND METHOD

A cooperative study was conducted at King Chulalongkorn Memorial hospital (Chula), Children hospital (CH), and Chiang Mai University hospital (CMU). The status of children who were referred for cardiac surgery at these hospitals in the year 1999-2000 (Chula and CMU) and the year 2000 (CH) were analyzed by Kaplan-Meier survival curve. The patients who lost to follow up and could not be contacted were censored at the time of last clinic visit. Log-Rank test was used to compare the survival curve and waiting time between three hospitals.

RESULTS

The averaged annual referrals for cardiac surgery at the three hospitals were 846 cases (205 for Chula, 462 for CH and 179 for CMU). Mean age was 4.3 +/- 4.2 years and 51% were male. Follow up data were complete in 96.3%. Surgical procedures were correction of simple shunt lesions (ASD, VSD, AV canal) in 33.9%, close heart surgery (PDA ligation, coarctation repair, BT shunt) in 29.9%, total repair TOF in 19.6%, complex surgery in neonate and infants (arterial switch, TAPVR repair, Norwood procedure, truncus and interrupted aortic arch repair) in 4.2% and others in 12.3%. Median waiting time was 195 days and was significantly different between the three hospitals (p < 0.01). Mortality while waiting were approximately 5% at 2 years at Chula and CH, which was significantly higher than CMU (0%, p = 0.02). Further analysis revealed difference in age (lower Chula than CH than CMU) and types of surgery (more complex at Chula and CH) which may be the causes for difference in the mortality observed.

CONCLUSION

Waiting time for cardiac surgery for children in Thailand is long and should be viewed as a problem in public health policy. Optimal waiting time at each hospital may not have to be the same, depending on the type and severity of the disease seen at each particular center Attempt should be made to solve this problem at the national level.

摘要

背景

需要进行心脏手术的泰国儿童通常会被列入等候名单。此前尚未对等候时间和等候期间的死亡率进行系统研究。

材料与方法

在朱拉隆功国王纪念医院(朱拉)、儿童医院(CH)和清迈大学医院(CMU)开展了一项合作研究。通过Kaplan-Meier生存曲线分析了1999 - 2000年(朱拉和CMU)以及2000年(CH)在这些医院被转诊进行心脏手术的儿童的情况。对失访且无法联系到的患者,在最后一次门诊就诊时进行截尾处理。采用对数秩检验比较三家医院的生存曲线和等候时间。

结果

三家医院每年平均转诊进行心脏手术的病例数为846例(朱拉205例,CH 462例,CMU 179例)。平均年龄为4.3±4.2岁,51%为男性。96.3%的患者有完整的随访数据。手术方式包括简单分流病变矫正(房间隔缺损、室间隔缺损、房室通道)占33.9%,闭合性心脏手术(动脉导管未闭结扎、缩窄修复、体肺分流)占29.9%,法洛四联症根治术占19.6%,新生儿及婴儿复杂手术(动脉调转术、完全性肺静脉异位引流修复术、诺伍德手术、永存动脉干及主动脉弓中断修复术)占4.2%,其他占12.3%。中位等候时间为195天,三家医院之间存在显著差异(p < 0.01)。在朱拉和CH等候2年时的死亡率约为5%,显著高于CMU(0%,p = 0.02)。进一步分析显示年龄(朱拉低于CH低于CMU)和手术类型(朱拉和CH的手术更复杂)的差异可能是观察到的死亡率差异的原因。

结论

泰国儿童心脏手术的等候时间较长,应被视为公共卫生政策中的一个问题。每家医院的最佳等候时间可能不必相同,这取决于每个特定中心所见到疾病的类型和严重程度。应尝试在国家层面解决这个问题。

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