van Schayck C P, Hogervorst J G F, de Kok T M C M, Briedé J J, Wesseling G, Kleinjans J C S
Universiteit Maastricht, Postbus 616, 6200 MD Maastricht.
Ned Tijdschr Geneeskd. 2006 Apr 1;150(13):735-40.
To determine whether or not there is a relationship between the lung function of school children and the ability of fine dust particles in the air to generate radicals.
Descriptive.
Six primary schools in locations with different traffic volumes were selected in Maastricht, the Netherlands. Air samples were taken in these schools over a period of 4 days; the concentration of fine dust was measured in the 6 pooled samples. Lung function tests were performed in children in the age of 8-13 and their parents filled out a questionnaire on the state of their children's health.
An average of 66% of the children (184 girls and 158 boys, with an average age of 10 years (range: 8-13 years)) participated. The average FEV1 for the children from the 6 schools was not related with the total amount of fine dust particles in the air. However, a lower average FEV1 was associated with a higher radical-generating capacity in the air samples. No direct association was observed between the radical-generating capacity of the dust and the traffic intensity.
There was a clear relationship between lung function and the radical-generating capacity of fine dust in the air. On the basis of these findings future guidelines could be based on chemical properties of the fine dust particles and not exclusively on the quantity of fine dust.
确定学童的肺功能与空气中细颗粒物产生自由基的能力之间是否存在关联。
描述性研究。
在荷兰马斯特里赫特选择了六所位于交通流量不同地区的小学。在这些学校采集了为期4天的空气样本；对6个混合样本中的细颗粒物浓度进行了测量。对8至13岁的儿童进行了肺功能测试，其父母填写了关于孩子健康状况的问卷。
平均66%的儿童（184名女孩和158名男孩，平均年龄10岁（范围：8至13岁））参与了研究。6所学校儿童的平均第一秒用力呼气量与空气中细颗粒物的总量无关。然而，较低的平均第一秒用力呼气量与空气样本中较高的自由基生成能力相关。未观察到灰尘的自由基生成能力与交通强度之间存在直接关联。
肺功能与空气中细颗粒物的自由基生成能力之间存在明显关联。基于这些发现，未来的指导方针可以基于细颗粒物的化学性质，而不仅仅基于细颗粒物的数量。
