McNaughton Brian R, Miller Benjamin L
Department of Chemistry, and The Center for Future Health, University of Rochester, Rochester, New York 14642, USA.
Org Lett. 2006 Apr 27;8(9):1803-6. doi: 10.1021/ol060330+.
[reaction: see text] Dynamic combinatorial chemistry (DCC) is a promising technique for receptor-aided selection of high-affinity ligands from equilibrating combinatorial libraries. Identification of the specific ligand(s) selected is often challenging, however, due to difficulties associated with chromatographic separation and/or mass degeneracy within the library. Herein, we describe proof-of-concept experiments demonstrating a new technique termed resin-bound DCC (RB-DCC), which provides a solution to this problem.
[反应：见正文] 动态组合化学（DCC）是一种很有前景的技术，可用于从平衡组合库中通过受体辅助筛选高亲和力配体。然而，由于与色谱分离和/或库内质量简并性相关的困难，鉴定所选择的特定配体往往具有挑战性。在此，我们描述了概念验证实验，展示了一种称为树脂结合DCC（RB-DCC）的新技术，它为解决这个问题提供了一种方法。
