Lo Simon S, Chang Eric L, Sloan Andrew E
Department of Radiation Oncology, Indiana Lions Gamma Knife Center, Indiana University Medical Center, 535 Barnhill Drive, RT 041, Indianapolis, IN 46202, USA.
Expert Rev Neurother. 2006 Apr;6(4):501-7. doi: 10.1586/14737175.6.4.501.
Ependymoma accounts for 5-10% of all childhood CNS tumors and less than 5% of intracranial tumors in adults. Ependymomas typically have a sharp tumor-brain parenchyma interface and this characteristic lends itself well to stereotactic radiation delivery. Data on the use of stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) for ependymoma in various settings have emerged over the past 10 years. SRS has been used in recurrent disease and as a boost after external beam radiation therapy. FSRT has been used in pediatric brain tumors and can potentially limit the long-term toxicities associated with radiation therapy by reducing the amount of normal brain parenchyma treated. Long-term follow-up is needed to determine the long-term efficacy and toxicities associated with these treatment modalities.
室管膜瘤占儿童所有中枢神经系统肿瘤的5%-10%，在成人颅内肿瘤中占比不到5%。室管膜瘤通常具有清晰的肿瘤-脑实质界面，这一特征使其非常适合立体定向放射治疗。在过去10年中，已经出现了关于在各种情况下使用立体定向放射外科（SRS）和分次立体定向放射治疗（FSRT）治疗室管膜瘤的数据。SRS已用于复发性疾病以及作为外照射放疗后的增强治疗。FSRT已用于小儿脑肿瘤，并且通过减少正常脑实质的受照量，有可能限制与放射治疗相关的长期毒性。需要长期随访以确定这些治疗方式的长期疗效和毒性。
