Krieger Mark D, McComb J Gordon
Division of Neurosurgery, Childrens Hospital Los Angeles, Los Angeles, CA, USA.
Childs Nerv Syst. 2009 Oct;25(10):1269-73. doi: 10.1007/s00381-009-0879-6. Epub 2009 Apr 9.
Intracranial ependymomas in children have high rates of recurrence. Salvage therapy typically includes repeat resection, possibly chemotherapy, and re-irradiation. Stereotactic radiosurgery has been used for re-irradiation. It offers the theoretical advantages of delivering a high dose of radiation to a small target, providing a maximum dose to the tumor while avoiding surrounding critical brain structures and previously irradiated tissue.
Few reports in the literature describe this technique, with mixed, but not often successful, outcomes.
儿童颅内室管膜瘤的复发率很高。挽救性治疗通常包括再次切除,可能还包括化疗和再次放疗。立体定向放射外科已被用于再次放疗。它具有将高剂量辐射传递到小靶点的理论优势,能在避免周围关键脑结构和先前照射组织的同时,为肿瘤提供最大剂量的辐射。
文献中很少有报道描述这种技术,其结果好坏参半,但并不常常成功。