基于微阵列技术对正常和恶性浆细胞的认识。
Microarray-based understanding of normal and malignant plasma cells.
作者信息
De Vos John, Hose Dirk, Rème Thierry, Tarte Karin, Moreaux Jérôme, Mahtouk Karéne, Jourdan Michel, Goldschmidt Hartmut, Rossi Jean-François, Cremer Friedrich W, Klein Bernard
机构信息
IRB, CHU Montpellier, Montpellier, France.
出版信息
Immunol Rev. 2006 Apr;210:86-104. doi: 10.1111/j.0105-2896.2006.00362.x.
Abstract
Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surface molecules such as CD138/syndecan-1, and for the unfolded protein response. We review how the microarray technology has recently contributed to the understanding of the biology of this rare but essential cell population and its transformation into premalignant and malignant PCs.
摘要
浆细胞（PCs）由抗原刺激后的B淋巴细胞发育而来，并表达一种旨在合成免疫球蛋白的基因程序。该程序包括诱导编码转录因子（如PRDM1、X盒结合蛋白1和BHLHB3）、细胞表面分子（如CD138/多配体蛋白聚糖-1）的基因以及未折叠蛋白反应相关基因。我们综述了微阵列技术最近如何有助于理解这种罕见但重要的细胞群体的生物学特性及其向癌前和恶性浆细胞的转化。
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