粪便白细胞检测能否很好地预测艰难梭菌相关性腹泻？
Is Fecal Leukocyte Test a good predictor of Clostridium difficile associated diarrhea?
作者信息
Reddymasu Savio, Sheth Ankur, Banks Daniel E
机构信息
Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
出版信息
Ann Clin Microbiol Antimicrob. 2006 Apr 19;5:9. doi: 10.1186/1476-0711-5-9.
Abstract
BACKGROUND
Fecal leukocyte test (FLT) is widely used to screen for invasive diarrheas including C. difficile associated diarrhea (CDAD), which account for more than 25 % of all antibiotic associated diarrhea.
METHOD
263 stool samples from patients with suspected CDAD were studied simultaneously for fecal leukocyte test (FLT) and Clostridium difficile toxin assay (CDTA). FLT was performed by the Giemsa technique and CDTA was performed by enzyme immuno assay (EIA).
RESULTS
Sensitivity, specificity, positive predictive value and negative predictive value of FLT as compared to CDTA were 30%, 74.9%, 13.2% and 89.3% respectively.
CONCLUSION
Considering the poor sensitivity of FLT, and the comparable cost and time of obtaining a CDTA at our institution, we conclude that FLT is not a good screening test for CDAD. Possible reasons for FLT being a poor predictor of CDTA are discussed.
摘要
背景
粪便白细胞检测（FLT）被广泛用于筛查包括艰难梭菌相关性腹泻（CDAD）在内的侵袭性腹泻，CDAD占所有抗生素相关性腹泻的25%以上。
方法
对263例疑似CDAD患者的粪便样本同时进行粪便白细胞检测（FLT）和艰难梭菌毒素检测（CDTA）。FLT采用吉姆萨技术进行，CDTA采用酶免疫测定（EIA）进行。
结果
与CDTA相比，FLT的敏感性、特异性、阳性预测值和阴性预测值分别为30%、74.9%、13.2%和89.3%。
结论
考虑到FLT的敏感性较差，且在我们机构获得CDTA的成本和时间相当，我们得出结论，FLT不是CDAD的良好筛查试验。讨论了FLT作为CDTA不良预测指标的可能原因。
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