Chikamatsu Kazuaki, Shino Masato, Fukuda Yoichiro, Sakakura Koichi, Furuya Nobuhiko
Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, 371-8511, Japan.
J Laryngol Otol. 2006 Apr;120(4):330-3. doi: 10.1017/S0022215106000296.
Salivary gland swelling is a commonly encountered clinical symptom, but the establishment of a diagnosis is occasionally difficult. Here, we present two sialodochitis fibrinosa patients with recurring bilateral parotid swelling. In both patients, secretion of mucous plugs containing numerous eosinophils was observed from Stensen's ducts. As expected, the level of interleukin-5 in the saliva was much higher than that in the serum. One patient had no medical history of allergic disease; the other had allergic rhinitis which had never been associated with parotid gland swelling. Microbiological examination was unable to isolate significant bacterial specimens from the mucous plugs. Thus, although allergy and/or bacterial infection are reportedly implicated as causes of sialodochitis fibrinosa, there may exist other possibilities for its pathogenesis. Interleukin-5 seems to play a crucial role in the pathogenesis of sialodochitis fibrinosa.
唾液腺肿大是一种常见的临床症状，但有时诊断起来颇具难度。在此，我们报告两例纤维蛋白性涎管炎患者，均出现双侧腮腺反复肿大。在这两名患者中，均观察到从腮腺导管分泌出含有大量嗜酸性粒细胞的黏液栓。不出所料，唾液中白细胞介素-5的水平远高于血清中的水平。其中一名患者无过敏性疾病病史；另一名患者有过敏性鼻炎，但从未与腮腺肿大相关联。微生物学检查未能从黏液栓中分离出重要的细菌标本。因此，尽管据报道过敏和/或细菌感染与纤维蛋白性涎管炎的病因有关，但其发病机制可能还存在其他可能性。白细胞介素-5似乎在纤维蛋白性涎管炎的发病机制中起着关键作用。
