Liu Ge-li, Fu Xiao-hui, Jiang Li-hong, Ma Xian-cheng, Yang Jing-yan
Department of Pediatrics, General Hospital of Tianjin Medical University, Tianjin 300052, China.
Zhonghua Er Ke Za Zhi. 2006 Feb;44(2):114-7.
Obesity is an important risk factor of insulin resistance and type 2 diabetes. Adipocyte is a cell that can actively secrete a series of factors to regulate the pathway responsible for energy balance. Resistin is one of these factors. The purpose of this study was to investigate possible correlation between resistin and certain parameters, including body parameters and other parameters of glucose metabolism and roles of resistin in hyperinsulinemia or insulin resistance in obese children.
The serum resistin concentration was measured in 34 obese children (18 boys, 16 girls; age 8.9-15.9 years) and 31 normal subjects (16 boys, 15 girls; age 7.8-14.5 years) by using ELISA. Anthropometric parameters, fasting glucose and insulin were measured in all subjects. Insulin resistance was assayed by homeostasis model assessment ratio (HOMA-R). Beta cell function was determined by using homeostasis model assessment beta cell (HOMA-beta). Correlation analysis was performed between resistin and other parameters.
(1) The serum resistin concentration (common logarithmic transformation) was 3.1 +/- 0.5 in obese subjects and 2.7 +/- 0.8 in normal subjects. (P < 0.05). (2) The serum resistin concentration was not significantly correlated with sex, age, systolic and diastolic blood pressures, but was positively correlated with BMI, percent body fat (BF%), waist-hip ratio (WHR) (r = 0.299, r = 0.304, r = 0.322, P < 0.01); and positively correlated with fasting glucose, insulin, HOMA-R (r = 0.299, r = 0.303, r = 0.324, P < 0.05), but not significantly correlated with HOMA-beta. (3) Multiple linear regression analysis showed that only HOMA-R was the factor that significantly influenced resistin, R(2) = 0.105, the standard partial coefficient was 0.279 (P < 0.01).
The serum resistin concentration in obese children were higher than that in normal children. The serum resistin concentration significantly correlated with the degree of obesity and the distribution of fat. Resistin is probably related to occurrence of hyperinsulinemia and/or insulin resistance in obese children.
肥胖是胰岛素抵抗和2型糖尿病的重要危险因素。脂肪细胞是一种能够主动分泌一系列因子来调节能量平衡相关途径的细胞。抵抗素就是这些因子之一。本研究的目的是探讨抵抗素与某些参数之间的可能相关性，包括身体参数以及葡萄糖代谢的其他参数，以及抵抗素在肥胖儿童高胰岛素血症或胰岛素抵抗中的作用。
采用酶联免疫吸附测定法（ELISA）测量34名肥胖儿童（18名男孩，16名女孩；年龄8.9 - 15.9岁）和31名正常受试者（16名男孩，15名女孩；年龄7.8 - 14.5岁）的血清抵抗素浓度。测量所有受试者的人体测量参数、空腹血糖和胰岛素水平。通过稳态模型评估比率（HOMA - R）测定胰岛素抵抗。使用稳态模型评估β细胞（HOMA - β）来确定β细胞功能。对抵抗素与其他参数进行相关性分析。
（1）肥胖受试者血清抵抗素浓度（常用对数转换后）为3.1±0.5，正常受试者为2.7±0.8。（P < 0.05）。（2）血清抵抗素浓度与性别、年龄、收缩压和舒张压无显著相关性，但与体重指数（BMI）、体脂百分比（BF%）、腰臀比（WHR）呈正相关（r = 0.299，r = 0.304，r = 0.322，P < 0.01）；与空腹血糖、胰岛素、HOMA - R呈正相关（r = 0.299，r = 0.303，r = 0.324，P < 0.05），但与HOMA - β无显著相关性。（3）多元线性回归分析显示，只有HOMA - R是显著影响抵抗素的因素，R（2） = 0.105，标准偏回归系数为0.279（P < 0.01）。
肥胖儿童血清抵抗素浓度高于正常儿童。血清抵抗素浓度与肥胖程度和脂肪分布显著相关。抵抗素可能与肥胖儿童高胰岛素血症和/或胰岛素抵抗的发生有关。
